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Frank's niece Amy starts work in the ED and makes a mistake which has tragic consequences for a patient. While treating a farmer brought into the ED after a tractor accident, Steve and Mike both go down with a mystery illness forcing Frank to take over an emergency surgery. Elsewhere, Erica looks after a young English woman dying from cystic fibrosis. Erica, Von and Bart try desperately to keep Stella alive long enough for her to be able to give her parents a final goodbye. Dan's pre-wedding night is ruined when he is witness to a tragedy.